Sébastien Guiral

Maître de conférences en Biochimie Microbiologie (Section 64)

Sébastien GUIRAL a obtenu son doctorat en 2004 à l’Université Paul Sabatier de Toulouse. Celui-ci portait sur la caractérisation du phénomène dit de fratricide chez la bactérie pathogène de l’homme Streptococcus pneumoniae. Un postdoctorat de 2 ans à l’INRA de Toulouse lui a ensuite permis de mettre en évidence des gènes potentiellement impliqués dans la virulence de la bactérie Mycoplasma agalactiae, un pathogène importants des ruminants. Recruté à l’Université Claude Bernard de Lyon comme maître de conférences, il a par la suite travaillé pendant plusieurs années à la compréhension du rôle joué par des protéines kinases bactériennes, en particulier chez Streptococcus pneumoniae, sur la physiologie bactérienne. Il apporte désormais ses compétences, notamment en génétique bactérienne, à la détermination de la fonction biologique des peptides retrouvés dans les venins de fourmis.

Contact :
sebastien.guiral@univ-jfc.fr
+33 5 63 48 91 45

Bibliographie

Carrouel F, Bourgeois D, Clement C, Tardivo C, Martinon P, Guiral S, Lan R, Viennot S, Dussart C, Fraticelli L (2022) Oral-hygiene-related mobile apps in the French app stores: assessment of functionality and quality. Int J Environ Res Public Health. 14;19(12):7293.

Diagne AM, Pelletier A, Durmort C, Faure A, Kanonenberg K, Freton C, Page A, Delolme F, Vorac J, Vallet S, Bellard L, Vivès C, Fieschi F, Vernet T, Rousselle P, Guiral S, Grangeasse C, Jault JM, Orelle C (2022) Identification of a two-component regulatory system involved in antimicrobial peptide resistance in Streptococcus pneumoniae. PLoS Pathog. 8;18(4):e1010458.

Pelletier A, Freton C, Gallay C, Trouve J, Cluzel C, Franz-Wachtel M, Macek B, Jault JM, Grangeasse C, Guiral S. (2019) The tyrosine-autokinase UbK is required for proper cell growth and cell morphology of Streptococcus pneumoniae. Front Microbiol. 3;10:1942. doi: 10.3389/fmicb.2019.01942. eCollection 2019.

Zucchini L, Mercy C, Garcia PS, Cluzel C, Gueguen-Chaignon V, Galisson F, Freton C, Guiral S, Brochier-Armanet C, Gouet P, Grangeasse C. (2018) PASTA repeats of the protein kinase StkP interconnect cell constriction and separation of Streptococcus pneumoniae. Nat Microbiol. 3(2):197-209. doi: 10.1038/s41564-017-0069-3.

Nguyen HA, El Khoury T, Guiral S, Laaberki MH, Candusso MP, Galisson F, Foucher AE, Kesraoui S, Ballut L, Vallet S, Orelle C, Zucchini L, Martin J, Page A, Attieh J, Aghajari N, Grangeasse C, Jault JM. (2017) Expanding the kinome world: a new protein kinase family widely conserved in bacteria. J Mol Biol. 13;429(20):3056-3074. doi: 10.1016/j.jmb.2017.08.016.

Nourikyan J, Kjos M, Mercy C, Cluzel C, Morlot C, Noirot-Gros MF, Guiral S, Lavergne JP, Veening JW, Grangeasse C. (2015) Autophosphorylation of the bacterial tyrosine-kinase CpsD connects capsule synthesis with the cell cycle in Streptococcus pneumoniae. PLoS Genet. 17;11(9):e1005518. doi: 10.1371/journal.pgen.1005518. eCollection 2015 Sep.

Fleurie A, Manuse S, Zhao C, Campo N, Cluzel C, Lavergne JP, Freton C, Combet C, Guiral S, Soufi B, Macek B, Kuru E, VanNieuwenhze MS, Brun YV, Di Guilmi AM, Claverys JP, Galinier A, Grangeasse C. (2014) Interplay of the serine/threonine-kinase StkP and the paralogs DivIVA and GpsB in pneumococcal cell elongation and division. PLoS Genet. 10;10(4):e1004275. doi: 10.1371/journal.pgen.1004275. eCollection 2014 Apr.

Fleurie A, Cluzel C, Guiral S, Freton C, Galisson F, Zanella-Cleon I, Di Guilmi AM, Grangeasse C. (2012) Mutational dissection of the S/T-kinase StkP reveals crucial roles in cell division of Streptococcus pneumoniae. Mol Microbiol. 83(4):746-58. doi: 10.1111/j.1365-2958.2011.07962.x.

Skapski A, Hygonenq MC, Sagné E, Guiral S, Citti C, Baranowski E. (2011) Genome-scale analysis of Mycoplasma agalactiae loci involved in interaction with host cells. PLoS One. 6(9):e25291. doi: 10.1371/journal.pone.0025291.

Baranowski E, Guiral S, Sagné E, Skapski A, Citti C. (2010) Critical role of dispensable genes in Mycoplasma agalactiae interaction with mammalian cells. Infect Immun. 78(4):1542-51. doi: 10.1128/IAI.01195-09.

Bechet E, Guiral S, Torres S, Mijakovic I, Cozzone AJ, Grangeasse C. (2009) Tyrosine-kinases in bacteria: from a matter of controversy to the status of key regulatory enzymes. Amino Acids. 37(3):499-507. doi: 10.1007/s00726-009-0237-8.

Guiral S, Hénard V, Laaberki MH, Granadel C, Prudhomme M, Martin B, Claverys JP. (2006) Construction and evaluation of a chromosomal expression platform (CEP) for ectopic, maltose-driven gene expression in Streptococcus pneumoniae. Microbiology. 152(Pt 2):343-9.

Guiral S, Hénard V, Granadel C, Martin B, Claverys JP. (2006) Inhibition of competence development in Streptococcus pneumoniae by increased basal-level expression of the ComDE two-component regulatory system. Microbiology. 152(Pt 2):323-31.

Guiral S, Mitchell TJ, Martin B, Claverys JP. (2005) Competence-programmed predation of noncompetent cells in the human pathogen Streptococcus pneumoniae: genetic requirements. Proc Natl Acad Sci U S A. 14;102(24):8710-5.

Dagkessamanskaia A, Moscoso M, Hénard V, Guiral S, Overweg K, Reuter M, Martin B, Wells J, Claverys JP. (2004) Interconnection of competence, stress and CiaR regulons in Streptococcus pneumoniae: competence triggers stationary phase autolysis of ciaR mutant cells. Mol Microbiol. 51(4):1071-86.

Bergès H, Checroun C, Guiral S, Garnerone AM, Boistard P, Batut J. (2001) A glutamine-amidotransferase-like protein modulates FixT anti-kinase activity in Sinorhizobium meliloti. BMC Microbiol. 1:6. doi: 10.1186/1471-2180-1-6. PMID: 11389771